Custody and counterparty
On Binance, deposits sit with the exchange and trading happens against an internal ledger. That brings deep liquidity, fiat rails and consumer support, at the cost of counterparty exposure to a single operator.
On Hyperliquid, an account is an onchain account. There is no operator ledger to reconcile and no discretionary control over positions — but also no support desk, no fiat on-ramp and no ability to reverse your own mistake.